Predicting disease genes using protein-protein interactions.

ABSTRACT:

Background

The responsible genes have not yet been identified for many genetically mapped disease loci. Physically interacting proteins tend to be involved in the same cellular process, and mutations in their genes may lead to similar disease phenotypes.

Objective

To investigate whether protein-protein interactions can predict genes for genetically heterogeneous diseases.

Methods

72,940 protein-protein interactions between 10,894 human proteins were used to search 432 loci for candidate disease genes representing 383 genetically heterogeneous hereditary diseases. For each disease, the protein interaction partners of its known causative genes were compared with the disease associated loci lacking identified causative genes. Interaction partners located within such loci

SUBMITTER: Oti M 

PROVIDER: S-EPMC2564594 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature