Survivin-directed RNA interference cocktail is a potent suppressor of tumour growth in vivo.

ABSTRACT:

Background

Survivin is proposed to play a central role in the progression and resistance to therapy of diverse tumour types. High levels of this molecule in tumour cells also correlate with loss of the TP53 tumour suppressor gene, suggesting a molecular connection between TP53 loss and transcriptional induction of Survivin. Patients with TP53 germline mutations, such as those with Li-Fraumeni syndrome, are particularly susceptible to sarcomas, including rhabdomyosarcomas. Our study aimed to identify rhabdomyosarcoma tumours that express Survivin, in order to test novel Survivin-targeted therapies in these tumours.

Methods

Tumour microarray slides composed of 63 primary rhabdomyosarcoma tumours were stained with a polyclonal antibody to Survivin to identify tumours expressing

SUBMITTER: Caldas H 

PROVIDER: S-EPMC2564625 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature