Congenital heart defects and genetic variants in the methylenetetrahydroflate reductase gene.

ABSTRACT:

Background

Most non-syndromic congenital heart defects (CHD) are caused by a complex interaction between maternal lifestyle factors, environmental exposures, and maternal and fetal genetic variants. Maternal periconceptional intake of folic acid containing vitamin supplements is reported to decrease the risk of CHD. The 677C-->T and 1298A-->C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene decrease enzyme activity.

Objective

To examine the relation between CHD and maternal and fetal MTHFR polymorphisms.

Methods

375 nuclear families were studied. The transmission/disequilibrium test was used to test for transmission distortion in complete triads. A log-linear approach was used to test for associations between CHD and maternal and offspring polymor

SUBMITTER: Hobbs CA 

PROVIDER: S-EPMC2564637 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature