Independent replication and initial fine mapping of 3p21-24 in Asperger syndrome.

ABSTRACT:

Background

Asperger syndrome is characterised by abnormalities in social interaction as well as repetitive and stereotyped behaviours and interests. The trait is thought to display complex inheritance, but in a subset of families the inheritance resembles the autosomal dominant model. Linkage to 3p14-24 has recently been reported in Asperger syndrome in Finnish families with a maximum multipoint NPL(all) of 3.32 at D3S2432.

Methods

We have replicated linkage findings to 3p21-24 in 12 new extended Asperger syndrome families. Linkage analyses were performed separately for the 12 new families, and linkage and association analyses were also performed jointly with data from the original genome-wide screen.

Results

Best two point and multipoint logarithm of the odds (LOD) s

SUBMITTER: Rehnstrom K 

PROVIDER: S-EPMC2564646 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature