Raised interleukin-10 is an indicator of poor outcome and enhanced systemic inflammation in patients with acute coronary syndrome.

ABSTRACT:

Objectives

To re-evaluate the relation between plasma interleukin-10 (IL-10) concentration at hospital admission and outcome and to investigate the impact of single nucleotide polymorphisms (SNP) in the IL-10 gene in patients with non-ST elevation acute coronary syndrome (ACS).

Design

Determination of IL-10 plasma concentrations and genotyping of SNPs in the IL-10 gene in a prospective trial of patients with ACS and in a group of healthy controls.

Patients

3179 patients in the Fragmin and fast revascularisation during InStability in Coronary artery disease II (FRISC II) trial and 393 healthy controls.

Main outcome measures

Mortality and incidence of myocardial infarction (MI) at 12 months.

Results

The median and interquartile ranges of IL-10 were 0.8 (0.

SUBMITTER: Malarstig A 

PROVIDER: S-EPMC2564840 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature