Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations.

ABSTRACT:

Background

IRF5 is a transcription factor involved both in the type I interferon and the toll-like receptor signalling pathways. Previously, IRF5 has been found to be associated with systemic lupus erythematosus, rheumatoid arthritis and inflammatory bowel diseases. Here we investigated whether polymorphisms in the IRF5 gene would be associated with yet another disease with features of autoimmunity, multiple sclerosis (MS).

Methods

We genotyped nine single nucleotide polymorphisms and one insertion-deletion polymorphism in the IRF5 gene in a collection of 2337 patients with MS and 2813 controls from three populations: two case-control cohorts from Spain and Sweden, and a set of MS trio families from Finland.

Results

Two single nucleotide polymorphism (SNPs) (rs4728142

SUBMITTER: Kristjansdottir G 

PROVIDER: S-EPMC2564860 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature