Chromosomal evolution of the PKD1 gene family in primates.

ABSTRACT:

Background

The autosomal dominant polycystic kidney disease (ADPKD) is mostly caused by mutations in the PKD1 (polycystic kidney disease 1) gene located in 16p13.3. Moreover, there are six pseudogenes of PKD1 that are located proximal to the master gene in 16p13.1. In contrast, no pseudogene could be detected in the mouse genome, only a single copy gene on chromosome 17. The question arises how the human situation originated phylogenetically. To address this question we applied comparative FISH-mapping of a human PKD1-containing genomic BAC clone and a PKD1-cDNA clone to chromosomes of a variety of primate species and the dog as a non-primate outgroup species.

Results

Comparative FISH with the PKD1-cDNA clone clearly shows that in all primate species studied distinct single

SUBMITTER: Kirsch S 

PROVIDER: S-EPMC2564946 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature