Individual disease risk and multimetric analysis of Crohn disease.

ABSTRACT: Rare dominant genes with high penetrance can be identified by linkage without inbreeding, whereas rare recessive genes with high penetrance are most efficiently recognized by autozygosity mapping of homozygotes in pedigrees with preferential inbreeding. On the contrary, complex inheritance is characterized by common genes with low penetrance, for which family studies and inbreeding are inefficient. Here, we develop the Fisherian theory for diallelic cases and controls, show that it compares favorably with Bayesian estimates, and evaluate their currently low power for discriminating cases and controls in Crohn disease (CD). Significance is enhanced by inclusion of composite likelihood, but identification of causal loci is delayed by low recognition of gene function. Clearly, association map

SUBMITTER: Gibson J 

PROVIDER: S-EPMC2564981 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature