HLA-driven convergence of HIV-1 viral subtypes B and F toward the adaptation to immune responses in human populations.

ABSTRACT:

Background

Cytotoxic T-Lymphocyte (CTL) response drives the evolution of HIV-1 at a host-level by selecting HLA-restricted escape mutations. Dissecting the dynamics of these escape mutations at a population-level would help to understand how HLA-mediated selection drives the evolution of HIV-1.

Methodology/principal findings

We undertook a study of the dynamics of HIV-1 CTL-escape mutations by analyzing through statistical approaches and phylogenetic methods the viral gene gag sequenced in plasma samples collected between the years 1987 and 2006 from 302 drug-naïve HIV-positive patients. By applying logistic regression models and after performing correction for multiple test, we identified 22 potential CTL-escape mutations (p-value<0.05; q-value<0.2); 10 of these association

SUBMITTER: Dilernia DA 

PROVIDER: S-EPMC2565011 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature