Alterations in immunological and neurological gene expression patterns in Alzheimer's disease tissues.

ABSTRACT: Microarray technology was utilized to isolate disease-specific changes in gene expression by sampling across inferior parietal lobes of patients suffering from late onset AD or non-AD-associated dementia and non-demented controls. Primary focus was placed on understanding how inflammation plays a role in AD pathogenesis. Gene ontology analysis revealed that the most differentially expressed genes related to nervous system development and function and neurological disease followed by genes involved in inflammation and immunological signaling. Pathway analysis also implicated a role for chemokines and their receptors, specifically CXCR4 and CCR3, in AD. Immunohistological analysis revealed that these chemokine receptors are upregulated in AD patients. Western analysis demonstrated an increas

SUBMITTER: Weeraratna AT 

PROVIDER: S-EPMC2565515 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature