Evolution and dynamics of regulatory architectures controlling polymyxin B resistance in enteric bacteria.

ABSTRACT: Complex genetic networks consist of structural modules that determine the levels and timing of a cellular response. While the functional properties of the regulatory architectures that make up these modules have been extensively studied, the evolutionary history of regulatory architectures has remained largely unexplored. Here, we investigate the transition between direct and indirect regulatory pathways governing inducible resistance to the antibiotic polymyxin B in enteric bacteria. We identify a novel regulatory architecture -- designated feedforward connector loop -- that relies on a regulatory protein that connects signal transduction systems post-translationally, allowing one system to respond to a signal activating another system. The feedforward connector loop is characterized by r

SUBMITTER: Mitrophanov AY 

PROVIDER: S-EPMC2565834 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature