Genome sequencing and analysis reveals possible determinants of Staphylococcus aureus nasal carriage.

ABSTRACT:

Background

Nasal carriage of Staphylococcus aureus is a major risk factor in clinical and community settings due to the range of etiologies caused by the organism. We have identified unique immunological and ultrastructural properties associated with nasal carriage isolates denoting a role for bacterial factors in nasal carriage. However, despite extensive molecular level characterizations by several groups suggesting factors necessary for colonization on nasal epithelium, genetic determinants of nasal carriage are unknown. Herein, we have set a genomic foundation for unraveling the bacterial determinants of nasal carriage in S. aureus.

Results

MLST analysis revealed no lineage specific differences between carrier and non-carrier strains suggesting a role for mobile genetic

SUBMITTER: Sivaraman K 

PROVIDER: S-EPMC2566312 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature