Phylogenetic and chromosomal analyses of multiple gene families syntenic with vertebrate Hox clusters.

ABSTRACT:

Background

Ever since the theory about two rounds of genome duplication (2R) in the vertebrate lineage was proposed, the Hox gene clusters have served as the prime example of quadruplicate paralogy in mammalian genomes. In teleost fishes, the observation of additional Hox clusters absent in other vertebrate lineages suggested a third tetraploidization (3R). Because the Hox clusters occupy a quite limited part of each chromosome, and are special in having position-dependent regulation within the multi-gene cluster, studies of syntenic gene families are needed to determine the extent of the duplicated chromosome segments. We have analyzed in detail 14 gene families that are syntenic with the Hox clusters to see if their phylogenies are compatible with the Hox duplications and the 2R/

SUBMITTER: Sundstrom G 

PROVIDER: S-EPMC2566581 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature