Association of complement factor H Y402H polymorphism with phenotype of neovascular age related macular degeneration in Israel.

ABSTRACT:

Purpose

The Tyr402His variant of complement factor H (CFH) is associated with age-related macular degeneration (AMD) in several populations. Our aim was to evaluate if this single nucleotide polymorphism (SNP) is associated with AMD in the Israeli population and see if it underlies heterogeneity in clinical manifestation and responses to photodynamic therapy (PDT), which characterize neovascular AMD (NVAMD).

Methods

Genotyping for the Tyr402His variant was performed in 240 NVAMD patients (78.1+/-7 age range) and 118 controls (70.8+/-8.2 age range). Genotyping was correlated with clinical characteristics and treatment parameters in sequential 131 NVAMD patients who underwent PDT.

Results

TheTyr402His coding allele was associated with NVAMD in the Israeli population: od

SUBMITTER: Chowers I 

PROVIDER: S-EPMC2566586 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature