Evolutionarily conserved transcriptional co-expression guiding embryonic stem cell differentiation.

ABSTRACT:

Background

Understanding the molecular mechanisms controlling pluripotency in embryonic stem cells (ESCs) is of central importance towards realizing their potentials in medicine and science. Cross-species examination of transcriptional co-expression allows elucidation of fundamental and species-specific mechanisms regulating ESC self-renewal or differentiation.

Methodology/principal findings

We examined transcriptional co-expression of ESCs from pathways to global networks under the framework of human-mouse comparisons. Using generalized singular value decomposition and comparative partition around medoids algorithms, evolutionarily conserved and divergent transcriptional co-expression regulating pluripotency were identified from ESC-critical pathways including ACTIVIN/NODAL

SUBMITTER: Sun Y 

PROVIDER: S-EPMC2566604 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature