Height and prostate cancer risk: a large nested case-control study (ProtecT) and meta-analysis.

ABSTRACT:

Background

Height, a marker of childhood environmental exposures, is positively associated with prostate cancer risk, perhaps through the insulin-like growth factor system. We investigated the relationship of prostate cancer with height and its components (leg and trunk length) in a nested case-control study and with height in a dose-response meta-analysis.

Methods

We nested a case-control study within a population-based randomized controlled trial evaluating treatments for localized prostate cancer in British men ages 50 to 69 years, including 1,357 cases detected through prostate-specific antigen testing and 7,990 controls (matched on age, general practice, assessment date). Nine bibliographic databases were searched systematically for studies on the height-prostate cancer

SUBMITTER: Zuccolo L 

PROVIDER: S-EPMC2566735 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature