Evolutionary analysis of the highly dynamic CHEK2 duplicon in anthropoids.

ABSTRACT:

Background

Segmental duplications (SDs) are euchromatic portions of genomic DNA (> or = 1 kb) that occur at more than one site within the genome, and typically share a high level of sequence identity (>90%). Approximately 5% of the human genome is composed of such duplicated sequences. Here we report the detailed investigation of CHEK2 duplications. CHEK2 is a multiorgan cancer susceptibility gene encoding a cell cycle checkpoint kinase acting in the DNA-damage response signalling pathway. The continuous presence of the CHEK2 gene in all eukaryotes and its important role in maintaining genome stability prompted us to investigate the duplicative evolution and phylogeny of CHEK2 and its paralogs during anthropoid evolution.

Results

To study CHEK2 duplicon evolution in anthropo

SUBMITTER: Munch C 

PROVIDER: S-EPMC2566985 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature