Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial.

ABSTRACT:

Background

Vitamin K has been widely promoted as a supplement for decreasing bone loss in postmenopausal women, but the long-term benefits and potential harms are unknown. This study was conducted to determine whether daily high-dose vitamin K1 supplementation safely reduces bone loss, bone turnover, and fractures.

Methods and findings

This single-center study was designed as a 2-y randomized, placebo-controlled, double-blind trial, extended for earlier participants for up to an additional 2 y because of interest in long-term safety and fractures. A total of 440 postmenopausal women with osteopenia were randomized to either 5 mg of vitamin K1 or placebo daily. Primary outcomes were changes in BMD at the lumbar spine and total hip at 2 y. Secondary outcomes included changes i

SUBMITTER: Cheung AM 

PROVIDER: S-EPMC2566998 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature