The ECM moves during primitive streak formation--computation of ECM versus cellular motion.

ABSTRACT: Galileo described the concept of motion relativity--motion with respect to a reference frame--in 1632. He noted that a person below deck would be unable to discern whether the boat was moving. Embryologists, while recognizing that embryonic tissues undergo large-scale deformations, have failed to account for relative motion when analyzing cell motility data. A century of scientific articles has advanced the concept that embryonic cells move ("migrate") in an autonomous fashion such that, as time progresses, the cells and their progeny assemble an embryo. In sharp contrast, the motion of the surrounding extracellular matrix scaffold has been largely ignored/overlooked. We developed computational/optical methods that measure the extent embryonic cells move relative to the extracellular matri

SUBMITTER: Zamir EA 

PROVIDER: S-EPMC2567004 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature