The diaphragm and lubricant gel for prevention of cervical sexually transmitted infections: results of a randomized controlled trial.

ABSTRACT:

Background

We evaluated the effectiveness of the Ortho All-Flex Diaphragm, lubricant gel (Replens) and condoms compared to condoms alone on the incidence of chlamydial and gonococcal infections in an open-label randomized controlled trial among women at risk of HIV/STI infections.

Methods

We randomized 5045 sexually-active women at three sites in Southern Africa. Participants who tested positive for curable STIs were treated prior to enrollment as per local guidelines. Women were followed quarterly and tested for Chlamydia trachomatis (CT) or Neisseria gonorrhoeae (GC) infection by nucleic-acid amplification testing (Roche Amplicor) using first-catch urine specimens. STIs detected at follow-up visits were treated. We compared the incidence of first infection after randomizat

SUBMITTER: Ramjee G 

PROVIDER: S-EPMC2567030 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature