Complete genome viral phylogenies suggests the concerted evolution of regulatory cores and accessory satellites.

ABSTRACT: We consider the concerted evolution of viral genomes in four families of DNA viruses. Given the high rate of horizontal gene transfer among viruses and their hosts, it is an open question as to how representative particular genes are of the evolutionary history of the complete genome. To address the concerted evolution of viral genes, we compared genomic evolution across four distinct, extant viral families. For all four viral families we constructed DNA-dependent DNA polymerase-based (DdDp) phylogenies and in addition, whole genome sequence, as quantitative descriptions of inter-genome relationships. We found that the history of the polymerase gene was highly predictive of the history of the genome as a whole, which we explain in terms of repeated, co-divergence events of the core DdDp ge

SUBMITTER: de Andrade Zanotto PM 

PROVIDER: S-EPMC2567038 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature