Trazodone for sleep disturbance after alcohol detoxification: a double-blind, placebo-controlled trial.

ABSTRACT:

Background

Trazodone is a commonly prescribed off-label for sleep disturbance in alcohol-dependent patients, but its safety and efficacy for this indication is unknown.

Methods

We conducted a randomized, double-blind, placebo-control trial of low-dose trazodone (50 to 150 mg at bedtime) for 12 weeks among 173 alcohol detoxification patients who reported current sleep disturbance on a validated measure of sleep quality or during prior periods of abstinence. Primary outcomes were the proportion of days abstinent and drinks per drinking day over 6-months; sleep quality was also assessed.

Results

Urn randomization balanced baseline features among the 88 subjects who received trazodone and 85 who received placebo. The trazodone group experienced less improvement in the pro

SUBMITTER: Friedmann PD 

PROVIDER: S-EPMC2567128 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature