Dominance and the evolutionary accumulation of cis- and trans-effects on gene expression.

ABSTRACT: Gene expression levels appear to be under pervasive stabilizing selection. Yet the genetic architecture underlying abundant gene expression diversity within and between populations remains elusive. Here, we investigated the role of dominance in the segregation of cis- and trans-regulation within and between populations. We used chromosome substitution lines of Drosophila melanogaster to show that (i) >70% of the genes that are differentially expressed between two homozygous lines are masked in the heterozygous, suggesting that one of the substituted chromosomes contains a recessive allele; (ii) such large masking is already obtained with heterozygous chromosomes originating from the same population, with the time of divergence between chromosomes in heterozygous lines making only a small b

SUBMITTER: Lemos B 

PROVIDER: S-EPMC2567206 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature