Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution.

ABSTRACT:

Background

Most human endogenous retroviruses (HERVs) invaded our genome at least 25 million years ago. The majority of the viral genes are degenerated, since no selection preserves them within the genome. However, a few intact and very old HERV genes exist, and likely are beneficial for the host. We here address evolutionary aspects of two HERV-V envelope genes, ENVV1 and ENVV2, located in tandem and containing a long open reading frame.

Results

The ENVV2 gene is preserved with an intact reading frame during simian evolution, but none of the ENVV genes are found in the prosimian species tested. While we observe many transposon insertions in the gag and pol regions of the ERV-V2 provirus, the ENVV2 genes have escaped transposon crossfire in all species tested. Additional ana

SUBMITTER: Kjeldbjerg AL 

PROVIDER: S-EPMC2567338 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature