The BK-mediated fAHP is modulated by learning a hippocampus-dependent task.

ABSTRACT: Intrinsic excitability is a plastic property of cells that, along with synaptic changes, can be modulated by learning. Action potential (AP) height, width, and frequency are intrinsically controlled properties which rely on the activation of Na(+), Ca(2+), and K(+) channels in the dendritic, somatic, and axonal membranes. The fast after-hyperpolarization (fAHP) after an AP is partially responsible for determining the half-width and duration of the AP and thus Ca(2+) influx during the depolarization. In CA1 hippocampal pyramidal cells, the fAHP is carried by the voltage- and Ca(2+)-dependent BK channel. In addition to modulating the duration of the AP, the BK-mediated potassium current exerts control over the frequency of AP generation in response to a depolarizing input. These facts positi

SUBMITTER: Matthews EA 

PROVIDER: S-EPMC2567507 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature