Anti-mullerian hormone and inhibin B in the definition of ovarian aging and the menopause transition.

ABSTRACT:

Context/objective

The objective of the study was to determine whether anti-Mullerian hormone (AMH) and inhibin B are viable endocrine biomarkers for framing the menopause transition from initiation to the final menstrual period (FMP).

Design

We assayed AMH, inhibin B, and FSH in 300 archival follicular phase specimens from 50 women with six consecutive annual visits commencing in 1993 when all women were in the pre- and perimenopausal menopause stages. Subsequently each woman had a documented FMP. The assay results were fitted as individual-woman profiles and then related to time to FMP and age at FMP as outcomes.

Results

Based on annual values from six time points prior to the FMP, (log)AMH longitudinal profiles declined and were highly associated with a time point 5

SUBMITTER: Sowers MR 

PROVIDER: S-EPMC2567855 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature