'Linkage analysis of thyroid antibody production: evidence for shared susceptibility to clinical autoimmune thyroid disease.

ABSTRACT:

Context

Epidemiological data suggest a genetic susceptibility to thyroid antibody (TAb) production.

Objective

The objective of the study was to identify genetic loci that are linked with TAb production.

Design

The design of the study was a whole genome linkage study in families with clustering of thyroid autoimmunity.

Settings

The study took place at an academic medical center.

Participants

Participants included 102 multigenerational families (540 individuals) multiplex for autoimmune thyroid disease (AITD) and TAb production.

Main outcome measures

We computed two-point logarithm of odds (LOD) scores and multipoint heterogeneity LOD scores for 400 microsatellite markers spanning the entire human genome at an average distance of 10 cm (approximatel

SUBMITTER: Ban Y 

PROVIDER: S-EPMC2567858 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature