Bioinformatic and statistical analysis of the optic nerve head in a primate model of ocular hypertension.

ABSTRACT:

Background

The nonhuman primate model of glaucomatous optic neuropathy most faithfully reproduces the human disease. We used high-density oligonucleotide arrays to investigate whole genome transcriptional changes occurring at the optic nerve head during primate experimental glaucoma.

Results

Laser scarification of the trabecular meshwork of cynomolgus macaques produced elevated intraocular pressure that was monitored over time and led to varying degrees of damage in different samples. The macaques were examined clinically before enucleation and the myelinated optic nerves were processed post-mortem to determine the degree of neuronal loss. Global gene expression was examined in dissected optic nerve heads with Affymetrix GeneChip microarrays. We validated a subset of differe

SUBMITTER: Kompass KS 

PROVIDER: S-EPMC2567987 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature