The effects of timing of fine needle aspiration biopsies on gene expression profiles in breast cancers.

ABSTRACT:

Background

DNA microarray analysis has great potential to become an important clinical tool to individualize prognostication and treatment for breast cancer patients. However, with any emerging technology, there are many variables one must consider before bringing the technology to the bedside. There are already concerted efforts to standardize protocols and to improve reproducibility of DNA microarray. Our study examines one variable that is often overlooked, the timing of tissue acquisition, which may have a significant impact on the outcomes of DNA microarray analyses especially in studies that compare microarray data based on biospecimens taken in vivo and ex vivo.

Methods

From 16 patients, we obtained paired fine needle aspiration biopsies (FNABs) of breast cancers take

SUBMITTER: Wong V 

PROVIDER: S-EPMC2567989 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature