Identification of TER94, an AAA ATPase protein, as a Bam-dependent component of the Drosophila fusome.

ABSTRACT: The Drosophila fusome is a germ cell-specific organelle assembled from membrane skeletal proteins and membranous vesicles. Mutational studies that have examined inactivating alleles of fusome proteins indicate that the organelle plays central roles in germ cell differentiation. Although mutations in genes encoding skeletal fusome components prevent proper cyst formation, mutations in the bag-of-marbles gene disrupt the assembly of membranous cisternae within the fusome and block cystoblast differentiation altogether. To understand the relationship between fusome cisternae and cystoblast differentiation, we have begun to identify other proteins in this network of fusome tubules. In this article we present evidence that the fly homologue of the transitional endoplasmic reticulum ATPase (TER9

SUBMITTER: Leon A 

PROVIDER: S-EPMC25682 | biostudies-literature | 1999 Nov

REPOSITORIES: biostudies-literature