Ontology highlight
ABSTRACT:
SUBMITTER: Shen JC
PROVIDER: S-EPMC2569966 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Shen Jiang-Cheng JC Unoki Motoko M Ythier Damien D Duperray Alain A Varticovski Lyuba L Kumamoto Kensuke K Pedeux Remy R Harris Curtis C CC
Cancer research 20070301 6
Inhibitor of growth 4 (ING4) is a candidate tumor suppressor that plays a major role in gene regulation, cell cycle control, apoptosis, and angiogenesis. ING4 expression is down-regulated in glioblastoma cells and head and neck squamous cell carcinoma. Here, we identified liprin alpha1/PPFIA1, a cytoplasmic protein necessary for focal adhesion formation and axon guidance, as a novel interacting protein with ING4. ING4 and liprin alpha1 colocalized at lamellipodia in the vicinity of vinculin. Ove ...[more]