Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes.

ABSTRACT:

Objective

Type 2 diabetes is a common complex disorder with environmental and genetic components. We used a candidate gene-based approach to identify single nucleotide polymorphism (SNP) variants in 222 candidate genes that influence susceptibility to type 2 diabetes.

Research design and methods

In a case-control study of 1,161 type 2 diabetic subjects and 1,174 control Finns who are normal glucose tolerant, we genotyped 3,531 tagSNPs and annotation-based SNPs and imputed an additional 7,498 SNPs, providing 99.9% coverage of common HapMap variants in the 222 candidate genes. Selected SNPs were genotyped in an additional 1,211 type 2 diabetic case subjects and 1,259 control subjects who are normal glucose tolerant, also from Finland.

Results

Using SNP- and gene-based a

SUBMITTER: Gaulton KJ 

PROVIDER: S-EPMC2570412 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature