PCLO variants are nominally associated with early-onset type 2 diabetes and insulin resistance in Pima Indians.

ABSTRACT:

Objective

A prior genome-wide association (GWA) study in Pima Indians identified variants within PCLO that were associated with early-onset type 2 diabetes. PCLO encodes a presynaptic cytomatrix protein that functions as a Ca(2+) sensor that may be involved in insulin secretion and/or insulin action. Therefore, PCLO was analyzed as a candidate gene for type 2 diabetes.

Research design and methods

Sequencing of PCLO identified four nonsynonymous variants and a 10-amino acid insertion. These variants, together with 100 additional variants identified by sequencing or chosen from databases, were genotyped for association analysis in the same 895 subjects analyzed in the prior GWA study (300 case subjects with diabetes onset at aged <25 years, 334 nondiabetic control subjects age

SUBMITTER: Ma L 

PROVIDER: S-EPMC2570415 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature