Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals.

ABSTRACT: Endurance exercise training is accompanied by physiological changes that improve muscle function and performance. Several studies have demonstrated that markers of mitochondrial capacity are elevated, however, these studies tend to be performed ex vivo under conditions that yield maximal enzyme activities or in vivo but monitoring the response to exercise. Therefore, it is unclear whether basal mitochondrial metabolism is affected by exercise training. To explore whether resting muscle metabolism was altered in trained individuals in vivo, two independent parameters of metabolic function-tricarboxylic acid (TCA) cycle flux (V(TCA)), and ATP synthesis (V(ATP))-were assessed noninvasively by using magnetic resonance spectroscopy in a cohort of young endurance trained subjects (n = 7) and a g

SUBMITTER: Befroy DE 

PROVIDER: S-EPMC2570428 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature