Proteomic profiling of Plasmodium sporozoite maturation identifies new proteins essential for parasite development and infectivity.

ABSTRACT: Plasmodium falciparum sporozoites that develop and mature inside an Anopheles mosquito initiate a malaria infection in humans. Here we report the first proteomic comparison of different parasite stages from the mosquito -- early and late oocysts containing midgut sporozoites, and the mature, infectious salivary gland sporozoites. Despite the morphological similarity between midgut and salivary gland sporozoites, their proteomes are markedly different, in agreement with their increase in hepatocyte infectivity. The different sporozoite proteomes contain a large number of stage specific proteins whose annotation suggest an involvement in sporozoite maturation, motility, infection of the human host and associated metabolic adjustments. Analyses of proteins identified in the P. falciparum spor

SUBMITTER: Lasonder E 

PROVIDER: S-EPMC2570797 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature