Prediction of evolutionarily conserved interologs in Mus musculus.

ABSTRACT: BACKGROUND:Identification of protein-protein interactions is an important first step to understand living systems. High-throughput experimental approaches have accumulated large amount of information on protein-protein interactions in human and other model organisms. Such interaction information has been successfully transferred to other species, in which the experimental data are limited. However, the annotation transfer method could yield false positive interologs due to the lack of conservation of interactions when applied to phylogenetically distant organisms. RESULTS:To address this issue, we used phylogenetic profile method to filter false positives in interologs based on the notion that evolutionary conserved interactions show similar patterns of occurrence along the genomes. The ap

SUBMITTER: Yellaboina S 

PROVIDER: S-EPMC2571111 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature