Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies.

ABSTRACT: A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans has been accumulating over the last decade, in particular a large number of loci derived from recent genome wide association studies (GWAS). True complex disease-associated loci often exert modest effects, so their delineation currently requires integration of diverse phenotypic data from large studies to ensure robust meta-analyses. We have designed a gene-centric 50 K single nucleotide polymorphism (SNP) array to assess potentially relevant loci across a range of cardiovascular, metabolic and inflammatory syndromes. The array utilizes a "cosmopolitan" tagging approach to capture the genetic diversity across approximately 2,000 loci in populations represented in the HapMap and SeattleSNPs projects. The

SUBMITTER: Keating BJ 

PROVIDER: S-EPMC2571995 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature