PDLIM5 and susceptibility to bipolar disorder: a family-based association study and meta-analysis.

ABSTRACT:

Objectives

The postsynaptic density-95/discs large/zone occludens-1 (PDZ) domain and LIM (Lin-11, Isl-1, and Mec-3) domain 5 (PDLIM5) gene has been analyzed as a candidate gene for both schizophrenia and bipolar disorder (BP) in Japanese samples. We performed a family-based association study to test the hypothesis that variants in PDLIM5 increase susceptibility to BP in European-Americans and a meta-analysis to clarify whether there is a single marker consistently contributing to risk for BP.

Methods

Five single nucleotide polymorphisms in the PDLIM5 gene were genotyped in 290 European-American BP families. Programs Sibling-Transmission/Disequilibrium Test (sib_tdt) and PDTPHASE were used for allelic and haplotypic association, respectively. We carried out a meta-analysis co

SUBMITTER: Shi J 

PROVIDER: S-EPMC2572255 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature