Recovery of hyperphosphatoninism and renal phosphorus wasting one year after successful renal transplantation.

ABSTRACT:

Background and objectives

In the first months after successful kidney transplantation, hypophosphatemia and renal phosphorus wasting are common and related to inappropriately high parathyroid hormone (PTH) and fibroblast growth factor-23 (FGF-23) levels. Little is known about the long-term natural history of renal phosphorus homeostasis in renal transplant recipients.

Design, setting, participants

We prospectively followed parameters of mineral metabolism (including full-length PTH and FGF-23) in 50 renal transplant recipients at the time of transplantation (Tx), at month 3 (M3) and at month 12 (M12). Transplant recipients were (1:1) matched for estimated GFR with chronic kidney disease (CKD) patients.

Results

FGF-23 levels (Tx: 2816 [641 to 10665] versus M3: 73 [43 t

SUBMITTER: Evenepoel P 

PROVIDER: S-EPMC2572285 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature