Inhibition of G1P3 expression found in the differential display study on respiratory syncytial virus infection.

ABSTRACT:

Background

Respiratory syncytial virus (RSV) is the leading viral pathogen associated with bronchiolitis and lower respiratory tract disease in infants and young children worldwide. The respiratory epithelium is the primary initiator of pulmonary inflammation in RSV infections, which cause significant perturbations of global gene expression controlling multiple cellular processes. In this study, differential display reverse transcription polymerase chain reaction amplification was performed to examine mRNA expression in a human alveolar cell line (SPC-A1) infected with RSV.

Results

Of the 2,500 interpretable bands on denaturing polyacrylamide gels, 40 (1.6%) cDNA bands were differentially regulated by RSV, in which 28 (70%) appeared to be upregulated and another 12 (30%) app

SUBMITTER: Zhao D 

PROVIDER: S-EPMC2572611 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature