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Caspofungin-resistant Candida tropicalis strains causing breakthrough fungemia in patients at high risk for hematologic malignancies.

ABSTRACT: We identified three cases of C. tropicalis strains causing breakthrough fungemia in allogeneic stem cell recipients receiving caspofungin prophylaxis and treatment. Three genetically unrelated isolates with high echinocandin MICs were identified. Each strain carried a characteristic mutation conferring an amino acid substitution within Fks1p hot spot 1.

SUBMITTER: Garcia-Effron G 

PROVIDER: S-EPMC2573122 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature

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Caspofungin-resistant Candida tropicalis strains causing breakthrough fungemia in patients at high risk for hematologic malignancies.

Garcia-Effron Guillermo G   Kontoyiannis Dimitrios P DP   Lewis Russell E RE   Perlin David S DS  

Antimicrobial agents and chemotherapy 20080915 11

We identified three cases of C. tropicalis strains causing breakthrough fungemia in allogeneic stem cell recipients receiving caspofungin prophylaxis and treatment. Three genetically unrelated isolates with high echinocandin MICs were identified. Each strain carried a characteristic mutation conferring an amino acid substitution within Fks1p hot spot 1. ...[more]

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