Structural rearrangement within an enveloped virus upon binding to the host cell.

ABSTRACT: We have made the surprising discovery that the interactions of herpes simplex virus with its initial cell attachment receptor induce a rapid and highly efficient structural change in the tegument, the region of the virion situated between the membrane and the capsid. It has been known for nearly a decade that viruses can trigger host signaling pathways when they bind to receptors on the cell surface; however, until now there has been no evidence that a signal can be sent in reverse--from the "outside in"--across a viral membrane. Evidence for this signaling event was found during studies of UL16, a tegument protein that is conserved among all the herpesviruses. Previous work has demonstrated that UL16 is bound to capsids isolated from the cytoplasm of infected cells, but this interaction i

SUBMITTER: Meckes DG 

PROVIDER: S-EPMC2573199 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature