Within-host genetic diversity of endemic and emerging parvoviruses of dogs and cats.

ABSTRACT: Viral emergence can result from the adaptation of endemic pathogens to new or altered host environments, a process that is strongly influenced by the underlying sequence diversity. To determine the extent and structure of intrahost genetic diversity in a recently emerged single-stranded DNA virus, we analyzed viral population structures during natural infections of animals with canine parvovirus (CPV) or its ancestor, feline panleukopenia virus (FPV). We compared infections that occurred shortly after CPV emerged with more recent infections and examined the population structure of CPV after experimental cross-species transmission to cats. Infections with CPV and FPV showed limited genetic diversity regardless of the analyzed host tissue or year of isolation. Coinfections with genetically d

SUBMITTER: Hoelzer K 

PROVIDER: S-EPMC2573264 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature