Cellular phosphatases facilitate combinatorial processing of receptor-activated signals.

ABSTRACT:

Background

Although reciprocal regulation of protein phosphorylation represents a key aspect of signal transduction, a larger perspective on how these various interactions integrate to contribute towards signal processing is presently unclear. For example, a key unanswered question is that of how phosphatase-mediated regulation of phosphorylation at the individual nodes of the signaling network translates into modulation of the net signal output and, thereby, the cellular phenotypic response.

Results

To address the above question we, in the present study, examined the dynamics of signaling from the B cell antigen receptor (BCR) under conditions where individual cellular phosphatases were selectively depleted by siRNA. Results from such experiments revealed a highly enmeshed

SUBMITTER: Kumar D 

PROVIDER: S-EPMC2573882 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature