Calcium taste preferences: genetic analysis and genome screen of C57BL/6J x PWK/PhJ hybrid mice.

ABSTRACT: To characterize the genetic basis of voluntary calcium consumption, we tested C57BL/6J mice (B6; with low avidity for calcium), PWK/PhJ mice (PWK; with high avidity for calcium) and their F(1) and F(2) hybrids. All mice received a series of 96-h two-bottle preference tests with a choice between water and the following: 50 mm CaCl(2), 50 mm calcium lactate, 50 mm MgCl(2), 100 mm KCl, 100 mm NH(4)Cl, 100 mm NaCl, 5 mm citric acid, 30 microm quinine hydrochloride and 2 mm saccharin. Most frequency distributions of the parental and F(1) but not F(2) groups were normally distributed, and there were few sex differences. Reciprocal cross analysis showed that B6 x PWK F(1) mice had a non-specific elevation of fluid intake relative to PWK x B6 F(1) mice. In the F(2) mice, trait correlations were cl

SUBMITTER: Tordoff MG 

PROVIDER: S-EPMC2574724 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature