Variants in nicotinic receptors and risk for nicotine dependence.

ABSTRACT:

Objective

A recent study provisionally identified numerous genetic variants as risk factors for the transition from smoking to the development of nicotine dependence, including an amino acid change in the alpha5 nicotinic cholinergic receptor (CHRNA5). The purpose of this study was to replicate these findings in an independent data set and more thoroughly investigate the role of genetic variation in the cluster of physically linked nicotinic receptors, CHRNA5-CHRNA3-CHRNB4, and the risk of smoking.

Method

Individuals from 219 European American families (N=2,284) were genotyped across this gene cluster to test the genetic association with smoking. The frequency of the amino acid variant (rs16969968) was studied in 995 individuals from diverse ethnic populations. In vitro stud

SUBMITTER: Bierut LJ 

PROVIDER: S-EPMC2574742 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature