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NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B.

ABSTRACT: The NMR structure of budding yeast chaperone Chz1 complexed with histones H2A.Z-H2B has been determined. Chz1 forms a long irregular chain capped by two short alpha-helices, and uses both positively and negatively charged residues to stabilize the histone dimer. A molecular model that docks Chz1 onto the nucleosome has implications for its potential functions.

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC2574748 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature

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NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B.

Zhou Zheng Z   Feng Hanqiao H   Hansen D Flemming DF   Kato Hidenori H   Luk Ed E   Freedberg Daron I DI   Kay Lewis E LE   Wu Carl C   Bai Yawen Y  

Nature structural & molecular biology 20080720 8

The NMR structure of budding yeast chaperone Chz1 complexed with histones H2A.Z-H2B has been determined. Chz1 forms a long irregular chain capped by two short alpha-helices, and uses both positively and negatively charged residues to stabilize the histone dimer. A molecular model that docks Chz1 onto the nucleosome has implications for its potential functions. ...[more]

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