Integrative genomic data mining for discovery of potential blood-borne biomarkers for early diagnosis of cancer.

ABSTRACT:

Background

With the arrival of the postgenomic era, there is increasing interest in the discovery of biomarkers for the accurate diagnosis, prognosis, and early detection of cancer. Blood-borne cancer markers are favored by clinicians, because blood samples can be obtained and analyzed with relative ease. We have used a combined mining strategy based on an integrated cancer microarray platform, Oncomine, and the biomarker module of the Ingenuity Pathways Analysis (IPA) program to identify potential blood-based markers for six common human cancer types.

Methodology/principal findings

In the Oncomine platform, the genes overexpressed in cancer tissues relative to their corresponding normal tissues were filtered by Gene Ontology keywords, with the extracellular environment stip

SUBMITTER: Yang Y 

PROVIDER: S-EPMC2575235 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature