Genomic analysis of the relationship between gene expression variation and DNA polymorphism in Drosophila simulans.

ABSTRACT:

Background

Understanding how DNA sequence polymorphism relates to variation in gene expression is essential to connecting genotypic differences with phenotypic differences among individuals. Addressing this question requires linking population genomic data with gene expression variation.

Results

Using whole genome expression data and recent light shotgun genome sequencing of six Drosophila simulans genotypes, we assessed the relationship between expression variation in males and females and nucleotide polymorphism across thousands of loci. By examining sequence polymorphism in gene features, such as untranslated regions and introns, we find that genes showing greater variation in gene expression between genotypes also have higher levels of sequence polymorphism in many gene

SUBMITTER: Lawniczak MK 

PROVIDER: S-EPMC2575515 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature