Breast cancer susceptibility loci and mammographic density.

ABSTRACT:

Introduction

Recently, the Breast Cancer Association Consortium (BCAC) conducted a multi-stage genome-wide association study and identified 11 single nucleotide polymorphisms (SNPs) associated with breast cancer risk. Given the high degree of heritability of mammographic density and its strong association with breast cancer, it was hypothesised that breast cancer susceptibility loci may also be associated with breast density and provide insight into the biology of breast density and how it influences breast cancer risk.

Methods

We conducted an analysis in the Nurses' Health Study (n = 1121) to assess the relation between 11 breast cancer susceptibility loci and mammographic density. At the time of their mammogram, 217 women were premenopausal and 904 women were postmenopausa

SUBMITTER: Tamimi RM 

PROVIDER: S-EPMC2575539 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature